Unfortunately, short of sitting in a personal anechoic chamber, nothing will completely isolate you from sound, due to the physics of human hearing. You hear most of what you hear by means of your ears. Isolate®2 work by blocking sound from entering your ear canals. However, sound will still vibrate your skull, cheekbones and jaw, albeit vastly less than sound entering your ears would. This is called bone conduction.
What Isolate®2 earplugs do (when correctly fitted) is they turn the volume down drastically and across the audible frequency range in a much more effective way. Imagine the noise from a loud Rock Concert, now imagine that same noise but at the level of a household washing machine, this is the sort of levels of sound reduction you will experience with Isolate®2 ear protection.